ACMG Panel - Dante Labs

ACMG Panel

Regular price €49.00 EUR
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Please note that these reports are recommended only for Whole Genome Test with 30X and up coverage

(Not compatible with WGL Longreads sequencing test)

 

The Dante Labs 59 Gene Actionable Disorders Panel analyzes the 59 genes identified as medically actionable by the American College of Medical Genetics and Genomics (ACMG; Kalia et al., 2017).

These genes are medically actionable, with clinical management guidelines established for their associated conditions.

 

List of diseases screened:

  • Familial adenomatous polyposis (FAP)
  • Hereditary breast and ovarian cancer (HBOC)
  • Li-Fraumeni syndrome (LFS)
  • Peutz-Jeghers syndrome (PJS)
  • Lynch syndrome – also known as hereditary non-polyposis colorectal cancer (HNPCC)
  • MUTYH-associated polyposis (MAP)
  • Von Hippel-Lindau syndrome (VHL)
  • Multiple endocrine neoplasia type 1 (MEN1)
  • Multiple endocrine neoplasia type 2 (MEN2)
  • Familial medullary thyroid cancer
  • PTEN hamartoma tumor syndrome
  • Retinoblastoma
  • Hereditary paraganglioma-pheochromocytoma syndrome (PGL/PCC)
  • Tuberous sclerosis complex (TSC)
  • WT1-related Wilms tumor
  • Neurofibromatosis type 2 (NF2)
  • Juvenile polyposis syndrome (JPS)
  • Marfan syndrome
  • Loeys-Dietz syndrome (LDS)
  • Thoracic aortic aneurysms and/or dissections (TAAD)
  • Ehlers-Danlos syndrome, vascular type
  • Hypertrophic cardiomyopathy
  • Dilated cardiomyopathy
  • Catecholaminergic polymorphic ventricular tachycardia (CPVT)
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC)
  • Romano-Ward long-QT syndrome
  • Brugada syndrome (BrS)
  • Familial hypercholesterolemia (FH)
  • Wilson disease
  • Malignant hyperthermia susceptibility (MHS)
  • Ornithine transcarbamylase (OTC) deficiency



List of genes:

ACTA2
ACTC1
APC
APOB
ATP7B
BMPR1A
BRCA1
BRCA2
CACNA1S
COL3A1
DSC2
DSG2
DSP
FBN1
GLA
KCNH2
KCNQ1
LDLR
LMNA
MEN1
MLH1
MSH2
MSH6
MUTYH
MYBPC3
MYH11
MYH7
MYL2
MYL3
NF2
OTC
PCSK9
PKP2
PMS2
PRKAG2
PTEN
RB1
RET
RYR1
RYR2
SCN5A
SDHAF2
SDHB
SDHC
SDHD
SMAD3
SMAD4
STK11
TGFBR1
TGFBR2
TMEM43
TNNI3
TNNT2
TP53
TPM1
TSC1
TSC2
VHL
WT1

We use a cutting-edge form of technology that not even the most advanced hospitals can provide and that allows us to sequenced your entire DNA with unparalleled precision, instead of focusing on only small parts of the DNA. 
Our Sequencing Center is located in L'Aquila, Italy, and with its 900 square-meter fully dedicated to Whole Genome Sequencing is considered Europe's largest private NGS laboratory. 

We perform all our analysis internally and thanks to our high-throughput next generation sequencing (NGS) equipment we guarantee superior quality.

Your sample and data will stay in the European Union (also if you are a US resident) and is protected by the EU General Data Protection Regulation (GDPR). Our technology offers data protection improvements not required by law but considered best practices in the industry.