Gilbert Syndrome Panel
Gilbert Syndrome Panel
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€29.00 EUR
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€29.00 EUR
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Gilbert's syndrome is not a disease, but a relatively common and harmless medical condition characterized by an impaired ability of the liver to process bilirubin.
Bilirubin is a by-product of the physiological process of haemocateresis (destruction) of red blood cells, after a life cycle of about three months. This yellow-orange molecule is eliminated from the body after chemical transformations that take place in the liver, aimed at converting it from the toxic form (unconjugated bilirubin) to the non-toxic form (conjugated bilirubin). In Gilbert syndrome, due to mutations in the UGT1A1 gene, bilirubin remains in the unconjugated form, resulting in episodes of hyperbilirubinemia.
Gilbert's syndrome is generally identified in adolescence and affected subjects undergo episodes of hyperbilirubinemia following physical stress such as fasting, dehydration or illness. Associated symptoms include vague abdominal pain, dyspepsia, fatigue and jaundice.
The 30% of subjects are asymptomatic: in this case, the syndrome is detected accidentally through routine examinations.
This monogenic panel analyzes the gene associated with Gilbert's syndrome.
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Bilirubin is a by-product of the physiological process of haemocateresis (destruction) of red blood cells, after a life cycle of about three months. This yellow-orange molecule is eliminated from the body after chemical transformations that take place in the liver, aimed at converting it from the toxic form (unconjugated bilirubin) to the non-toxic form (conjugated bilirubin). In Gilbert syndrome, due to mutations in the UGT1A1 gene, bilirubin remains in the unconjugated form, resulting in episodes of hyperbilirubinemia.
Gilbert's syndrome is generally identified in adolescence and affected subjects undergo episodes of hyperbilirubinemia following physical stress such as fasting, dehydration or illness. Associated symptoms include vague abdominal pain, dyspepsia, fatigue and jaundice.
The 30% of subjects are asymptomatic: in this case, the syndrome is detected accidentally through routine examinations.
This monogenic panel analyzes the gene associated with Gilbert's syndrome.
Ce produit est uniquement destiné aux clients qui ont déjà acheté un test MyGenome.