900 square-meter DNA Sequencing Center fully dedicated to Whole Genome Sequencing 900 square-meter DNA Sequencing Center fully dedicated to Whole Genome Sequencing
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Introducing Dante Labs Business: A B2B Portal for Advanced Genetics Dedicated to Healthcare Professionals and Researchers

Introducing Dante Labs Business: A B2B Portal for Advanced Genetics Dedicated to Healthcare Professionals and Researchers

London, May 28, 2019 (Newswire.com) - Dante Labs today announced the launch of Dante Labs Business for Healthcare Professionals and Researchers (http://b2b.dantelabs.com), a new portal that combines the advanced analytics, access to newest technologies and genetics expertise that thousands of individuals have come to know and love from Dante Labs, with new features and exclusive services tailored for healthcare professionals and researchers.

Dante Labs B2B customers will find tests and reports for their needs, special business-only pricing and billing. New services will be launched in the coming months, which leverage the power of sequencing in the research and healthcare space.

Some of the tests available to healthcare professionals and researchers include:

  • Pharmacogenomic Tests
  • ACMG Panels
  • Immunology Panels
  • Long Read Whole Genome Sequencing

Customers have access to volume discounts, with different tiers.

“Private clinics and researchers have come to value the services and technical support of Dante Labs,” said Andrea Riposati, CEO of Dante Labs. “We have heard their requests for a more tailored online buying experience and for additional services that cannot be offered to individuals. We aim at bringing advanced genetics to all the researches and healthcare professionals that can’t afford to purchase and run their own sequencing equipment, and create their own reporting pipelines.”

New customers must request access to the Dante Labs B2B Portal, by registering on the website (http://b2b.dantelabs.com). Only accredited clinics, doctors, healthcare professionals, and researchers will be granted access.

To apply for a free Dante Labs B2B account, please visit b2b.dantelabs.com

 

Media Contact:

Francesco Pennelli

Phone: +39-3206-030072

Email: francesco@dantelabs.com

Our Response to the British Parliament Inquiry on Commercial Genomics

Our Response to the British Parliament Inquiry on Commercial Genomics

"We believe in freedom and knowledge. The DNA belongs to the individual. People have the right to learn about their DNA and have the right to choose." 

The Science and Technology Committee of the British Parliament launched an inquiry into commercial genetic testing.

We firmly believe in the freedom of choice. Both patients and healthy individuals benefit from being able to choose among different providers - commercial and public.

#dnachoice

Below is Dante Labs full submission to the inquiry.

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At Dante Labs, we welcome the interest in genetic tests by the Science and Technology Committee of the Parliament of the United Kingdom.

We hope that the inquiry launched on March 4, 2019, will bring the attention of the British government and other European and non-European governments to the importance of genetic tests in a modern healthcare system.

We would like to provide our feedback on four relevant topics:

  1. Benefits of commercial genetic tests for individuals and citizens

  2. Technology used by commercial genomic companies

  3. Interpretation of results

  4. Freedom of choice

 

Benefits of commercial genetic tests for individuals and citizens

Genome sequencing and genomic tests make a huge difference to the lives of patients with rare diseases. Many people with genetic diseases spend years in the “undiagnosed odyssey” before receiving a diagnosis. Commercial genomic tests empower healthcare professionals with the tools to provide more precise diagnoses and prescribe the most effective treatments.

Technology used by commercial genomic companies

The belief that commercial genomic companies use technology inferior to that of academic centers and hospitals is wrong; this idea is merely a myth. On the contrary, commercial genomic companies often have access to more modern genetic and sequencing technologies than local hospitals do. Moreover, companies with a global reach benefit from economies of scale; they can achieve lower costs than a local hospital and then pass these cost savings to the users. At Dante Labs, we benefit from serving people in 84 countries. We have built a flexible cost structure and pass the cost savings to our customers.

Interpretation of results

People are smart. Rare disease patients are extremely knowledgeable about their rare disease and often see one or more specialists. In our experience, less than 1% of Dante Labs’ users asked us for genetic counseling. None of these people put a burden on their local healthcare systems. On the contrary, many took their results to their physician, thus empowering the physician to take more informed actions regarding diagnosis, treatment, and reaction to medications (pharmacogenomics).

Freedom of choice

Finally, we believe in freedom and knowledge. DNA belongs to the individuals. People have the right to learn about their DNA and have the right to choose where to get their DNA analyzed. Genomic testing companies provide people with more options and more offerings, and they motivate each other to constantly innovate to provide broader and deeper analysis for their users.

Renewing our excitement for the interest in genomic testing by the Parliament of the United Kingdom, we welcome further discussions with the Science and Technology Committee and wish to reiterate the importance of choice in accessing multiple options for genomic testing.

 

Genetic Data: FASTQ, BAM and VCF

Genetic Data: FASTQ, BAM and VCF

With Dante Labs whole genomes, you always get your raw data. We give raw data because it represents your DNA, is yours, and is an asset for life: in the next months and years you will be able to use your raw data on new tools, by Dante Labs and by other organizations. 

Instead of keeping the raw data and forcing you to return to us, we give you the raw data. 

Raw data can be confusing. It is a lot of files. Some are very large and hard to understand.

In a nutshell:

  • the VCF SNP is the most commonly used file (ex. on third party websites), followed by the VCF INDEL

  • if you don't know what the FASTQ or BAM files are, it will be very hard to read them (they are 100 GB each and requires bioinformatics knowledge)

The table below has a short description that we hope you may find useful to understand what files you will receive by Dante Labs. 

When you sequence your genome with Dante Labs (Whole Genome, Whole GenomeZ, Whole GenomeL), you will get this data:

SNP VCF SNP

VCF stands for Variant Call Format. It is a standardized text file format for representing SNP, INDEL, SV and CNV variation calls.

SNPs (Single Sucleotide Polymorphisms, pronounced “snips”), are the most common type of genetic variation among people. Each SNP represents a difference in a single DNA building block, called a nucleotide.

This is the most used VCF (ex. on third party tools like Sequencing.com)

INDEL VCF INDEL

Indel is a molecular biology term for insertions or deletions in your DNA. The number of INDELs in human genomes is second only to the number of SNPs. They have a key role in your genetics.

SV VCF SV

SVs, or Structural Variants, are large DNA sequences that are inserted, inverted, deleted or duplicated within genomes.

CNV VCF CNV

A CNV (copy number variation) is when the number of copies of a particular gene varies from one individual to the next. Some cancers are believed to be associated with elevated copy numbers of particular genes.

BAM BAM

Binary Alignment Map (BAM) is the comprehensive raw data of genome sequencing; it consists of the lossless, compressed binary representation of the Sequence Alignment Map. BAM files are 90-100 gigabytes in size. They are generated by aligning the FASTQ files to the reference genome.

 FASTQ File FASTQ

FASTQ files contain billions of entries and are about 90-100 gigabytes in size, making them too large to open in a normal text editor. FASTQ files are the ultimate raw data.

 

If you are interested to learn more, we suggest: