Frequently asked questions
Everything you need to know about Dante Labs whole genome sequencing — from ordering your kit to understanding your results.
What is whole genome sequencing?
Whole genome sequencing (WGS) reads your entire DNA — all 6.4 billion base pairs, every gene, and every region between genes. Unlike targeted genetic tests that check a pre-selected set of markers, whole genome sequencing provides the complete genetic picture. Dante Labs performs clinical-grade 30X whole genome sequencing, the gold standard for high-confidence variant calls and interpretation.
Consumer DNA tests like 23andMe and AncestryDNA use genotyping, which reads less than 0.1% of your genome — a pre-selected set of known markers. Dante Labs sequences your full genome at 30X clinical-grade coverage, identifying 4.6–5 million variants per test. This includes rare variants, structural changes, and regions that no targeted test was designed to check.
30X coverage means that, on average, every position in your genome is read 30 times. This redundancy ensures 99.98% sequencing accuracy and is the standard used in clinical diagnostics. Higher coverage means higher confidence in every variant identified.
Dante provides 200+ physician-ready clinical reports organized by category — including cardiac conditions, hereditary cancer risk, neurological conditions, rare diseases, and pharmacogenomics. Reports are delivered through your Genome Manager portal and can be shared directly with your clinical team.
Yes. Your DNA does not change, but genome science is accelerating. Every month, new variant-disease associations are discovered. Dante validates these findings and updates your reports automatically. Once your genome is sequenced, you can also add new reports later without providing a new sample. Your test becomes more valuable every year.
Yes. If you have already been tested by another company (such as 23andMe, AncestryDNA, or another provider), you can upload your existing DNA data to the Dante Labs platform to access our clinical-grade reports and interpretation. Visit the Upgrade page for details.
Yes. Because you share DNA with your biological relatives, your whole genome results can provide meaningful insight into conditions that may affect family members. If your report identifies a pathogenic variant in a gene associated with hereditary cancer, cardiac conditions, or other heritable diseases, that finding is directly relevant to parents, siblings, and children who share that genetic lineage.
No. Whole exome sequencing (WES) reads only the protein-coding regions of your genome — roughly 1–2% of your total DNA. Whole genome sequencing (WGS) reads everything: all 6.4 billion base pairs, including the regulatory, intronic, and intergenic regions that exome sequencing misses. Many clinically significant variants are found outside the exome, making WGS the more comprehensive approach.
Ordering, collection, and process
Choose your test, place your order, and a collection kit ships directly to your home. The kit includes clear instructions for sample collection. No clinic visit or blood draw required.
A simple saliva sample. The kit uses a SpectrumDNA collection tube — you spit into the tube, seal it, and return it in the prepaid shipping box included with your kit. No needles, no blood draw.
No. Dante Labs whole genome sequencing is available direct to consumer. You can order your kit without a prescription or referral. However, we recommend discussing your results with a healthcare professional for clinical interpretation and any follow-up action.
Your sample is processed in CLIA-certified, CAP-accredited partner laboratories in the US and EU. Genomic data processing takes place at our partner laboratory in Italy, under EU jurisdiction and GDPR framework. All laboratories hold ISO 15189 medical lab accreditation.
Yes. Dante Labs ships worldwide and serves customers in over 100 countries. Free shipping is included with every order. Your sample is returned using the prepaid shipping materials included in your kit, regardless of your location.
Understanding and using your reports
All reports are delivered to your secure Genome Manager portal. You can view, download, and share reports directly with your doctor or clinical team. Raw data files (FASTQ, BAM, VCF) can also be requested or downloaded where available.
Genome Manager is Dante's proprietary platform for accessing your complete genome data. It includes AI Genome Chat — so you can ask questions about your results in plain language — physician-ready report outputs, family profile management, and the ability to share reports directly with your clinical team.
Yes. Reports are designed to be physician-ready — formatted for clinical review, not just personal curiosity. You can share reports directly from your Genome Manager account, or download them to bring to an appointment. Dante results have been reviewed and accepted by clinical teams at named institutions including NHS hospitals.
If your reports identify clinically significant variants, we recommend sharing the results with your doctor or a genetic counselor. Dante reports are classified using ACMG guidelines (the standard framework used by clinical geneticists). Your healthcare professional can use these reports to inform next steps — whether that means additional testing, screening, or changes to your care plan.
For physicians and clinical teams
Dante Labs testing is performed through CLIA-certified, CAP-accredited partner laboratories. Variants are classified according to ACMG guidelines. Results have been reviewed and accepted by clinical teams at named institutions — including NHS genetics at Queen Elizabeth University Hospital Glasgow, where Dante's whole genome sequencing data was used to identify Noonan Syndrome and a rare RUNX1 deficiency in a documented clinical case.
Testing is performed through CLIA-certified, CAP-accredited partner laboratories. Dante holds ISO 15189 (medical laboratory), ISO 9001 (quality management), and ISO 13485 (medical devices) certifications. Data handling is compliant with both HIPAA and GDPR.
Yes. Dante offers a B2B portal (Dante Genomics) for clinicians and institutions. The Genome Manager platform allows registration of patient kits, step-by-step genome analysis monitoring, and secure results delivery — all processed under EU GDPR regulations and HIPAA.
Yes. Dante's whole genome sequencing data is designed to complement — not replace — existing clinical pathways. The data can be used by clinical genetics teams to inform diagnostic decisions, guide treatment plans, and identify hereditary risk that may cascade to family members. Dante has generated more than 1.3 million genomic reports delivered to users in over 100 countries.
How your data is protected
You do. You control your data — you can download it, delete it, or anonymize it at any time from your account or by contacting support. Dante does not sell your personal information or genomic data.
No. Your data is never sold, shared, or used for third-party research without your explicit consent. Dante Labs operates as a Data Controller under the EU's General Data Protection Regulation (GDPR).
Your biological sample is destroyed after the results are ready and available in your personal account. Your report and results are kept available until account deactivation, after which personal data is retained for 10 years solely to comply with legal obligations.
Yes. Dante Labs (Dante Labs S.r.l.) operates as a Data Controller under GDPR (Regulation (EU) 2016/679). All activity is performed within the EU and the US, fully compliant with GDPR. Data handling also meets HIPAA requirements for US patients. All data is processed according to EU GDPR regulations and is never shared or sold.
Delivery, timelines, and pricing
Kits ship within 48 hours of placing your order. Typical delivery time is 3–7 business days depending on your region. Shipping is free worldwide, and a prepaid return box is included with your kit.
Yes. Dante Labs ships worldwide and has delivered genomic reports to users in over 100 countries. Free shipping is included with every order.
Whole genome sequencing results are typically delivered in 6–8 weeks once your sample arrives at the lab. You'll receive status updates by email at each step of the process. RNA and multi-omics tests take approximately 4–6 weeks.
Dante Labs whole genome sequencing starts at . This includes 30X clinical-grade sequencing, 200+ physician-ready reports, lifetime access to your Genome Manager portal, and automatic report updates as new variant-disease associations are discovered. Free worldwide shipping is included.
You can reach Dante Labs support at our Contact page or email hello@dantelabs.com. The team typically responds within 24 hours.
Dante Labs offers a satisfaction guarantee. If your kit has not been activated, you can return it for a full refund. Once your sample has been submitted and sequencing has begun, the service is non-refundable — as laboratory resources have been committed to processing your genome. For specific questions about your order, contact our support team.
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Our team typically responds within 24 hours. Reach out and we'll get back to you.
Contact us →One test.
A lifetime of answers.
One kit, sent to your home. Your entire genome sequenced at the clinical standard used for diagnostic decisions. 200+ physician-ready reports delivered to your Genome Manager in 6–8 weeks — permanent and updated as science advances.
Ships within 48 hours · Results in 6–8 weeks
